At that time, the curriculum was focused on classical studies and philosophy, but as the university grew and expanded, so did the College of Arts and Letters.

Today, the college offers over 20 majors and 30 minors, including anthropology, economics, philosophy, and studio art.

The main center of the college is O'Shaughnessy Hall, which hosts classrooms, art galleries, a coffee shop, and administrative offices.

[5] Its Great Hall, which is decorated and sculpted on the outside, features a crucifix by Croatian sculptor Ivan Meštrović, a bust of Dean Charles E. Sheedy, and 7 stained glass windows, representing the seven liberal arts.

Corbett Family Hall, which is part of the Campus Crossroads expansion of the Notre Dame Stadium, houses the Departments of Anthropology and Psychology.

[9] The second floor houses the Department of Anthropology, with research laboratories, offices, study and meeting rooms, classrooms, and social events spaces .

The anthropology and psychology departments, both in the College of Arts and Letters, were scattered around campus and without a single location before the opening of Corbett.

The building, which built in 1917 as a chemistry hall, was renovated in 1982 thanks to a donation from Allan Riley, real estate investor and 1957 graduate.

[13] The department also houses its graphic and industrial design programs in the recently renovated West Lake hall.

[18] The Music department is housed in O'Neill Hall, also part of the Campus Crossroads project and on the Notre Dame Stadium.

The fifth and sixths floors of O'Neill Hall are dedicated to the Sacred Music Program and house departmental offices, teaching studios and practice rooms.

[21] "Justice education," "Research for the Common Good," and "Consequential Conservations," are the three avenues that the center for social concerns explores.

[22] Established in 1991 with a gift from Donald Keough, the institute focused on the study of Ireland and Irish culture, language, immigration, and history.

The institute is located of the university's Global gateway in Dublin, which is based at O'Connell House, a late eighteenth-century building on Merrion Square, which enables students to study abroad in Ireland.

[26][27] Its rare book collection contains holds microfilms and photographic copies of nearly all of the Latin and vernacular materials and many of those in Greek, Hebrew, and Arabic housed in the great Biblioteca Ambrosiana in Milan.

[28] This collection was conceived in 1960, when the Archbishop of Milan, Cardinal Giovanni Montini (future Pope Paul VI) visited campus for an honorary degree.

[36][37][38] The Liu Institute provides a hub for multidisciplinary research and education on Asia as well as its diaspora, including by hosting public events and promoting international exchanges.

[39] Established in 2017, the Ansari Institute helps facilitate inter-religious dialogue between those in the religious communities, with the goals of promoting inter-religious tolerance and learning from a variety of religions in order to work towards the common good, advancing not only the interests of the institute, but the interests of the Keough School of Global Affairs as well as the goals of the university as a whole.

[41] The Lucy Family Institute serves as a point of collaboration between the humanities and data science, AI, and machine learning.