Nové Zámky District (okres Nové Zámky) is a district in the Nitra Region of western Slovakia.

Until 1918, the area of the district was split between several counties of the Kingdom of Hungary: the largest area in the north formed part of Nitra; an area in the south between Dvory nad Žitavou and Strekov formed part of Komárno; an area in the north-east around Veľké Lovce formed part of Tekov; a sizable area in the east formed part of Esztergom (Ostrihom); and a small area around Salka formed part of Hont County.

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