It was formed on 20 December 1920 from the parts Wilno, Brześć, Mińsk Districts of the freshly disestablished Provisional Administration of Front-line and Phase Territories.

The region was governed by the Chief of District, a public official, who was a representative of the Council of Ministers, responsible for the implementation of the laws as well as superior to local administration offices.

[1] From Wilno District were included eight counties: Brasław (excluding six municipalities incorporated into Latvia in June 1920), Duniłowicze (inclucing town of Dokshytsy and Gmina Dokszyce from Mińsk District), Dzisna, Grodno, Lida, Nowogródek, Wilejka (excluding southeaster borderlands) and Wołożyn.

From Brześć District were included 4 counties: Baranowicze, Nieśwież (inclucing Hrycewicze and Teladowicze municipalities from Mińsk District), Słonim and Wołkowysk.

On 14 August 1921, counties of Grodno and Wołkowysk were incorporated into freshly established Białystok Voivodeship.