Mexicana Universal Puebla is a pageant in Puebla, Mexico, that selects that state's representative for the national Mexicana Universal pageant.

The State Organization has produced two Nuestra Belleza Mundo México titleholder in 2002 with Blanca Zumárraga and 2005 with Karla Jiménez.

Mexicana Universal Puebla winners have gone on to win Nuestra Belleza México twice.

Below are the names of the annual titleholders of Mexicana Universal Puebla, listed in ascending order, and their final placements in the Mexicana Universal after their participation, until 2017 the names are as Nuestra Belleza Puebla.

As of 2000, it is not uncommon for some States to have more than one delegate competing simultaneously in the national pageant.