The Jesuits learned Indian languages and developed ways to write them using the Roman alphabet.

Not only did the Jesuits print works in Spanish and Latin (the language of the Catholic liturgy, Bible and prayer book), but they translated the Bible and other Christian works into Indian languages, as well as printing dictionaries.

He was particularly known as a linguist and missionary to the Moro people; he worked in the region from 1696 and served as Superior of the Mission several times.

In 1984 it was one of four reducciones in Argentina (others were San Ignacio Mini, Nuestra Señora de Santa Ana, and Santa María la Mayor) and São Miguel das Missões in Brazil designated as World Heritage Sites by UNESCO.

[1] Vegetation has grown over and contributed to deterioration of the ruins, which are not as well preserved as those of San Ignacio Miní, also in Misiones.