Nullarbor Regional Reserve is a protected area in South Australia located about 300 kilometres (190 miles) west of Ceduna.

Its boundaries are defined by the Trans-Australian Railway to the north and by the Nullarbor National Park, the Nullarbor Wilderness Protection Area and the Yalata Indigenous Protected Area to the south.

[3][4][5] The northeastern corner of the reserve is the locations of Ooldea, and central north Cook on the railway line,[4] and the northern boundary is adjacent to the Maralinga Tjarutja Aboriginal lands.

[citation needed] The Nullarbor Regional Reserve and the adjoining Nullarbor National Park protect the world's largest semi-arid cave landscape, which is associated with many Aboriginal cultural sites.

[citation needed] Wildlife inhabiting in the regional reserve includes the Southern Hairy-nosed Wombat The regional reserve is classified as an IUCN Category VI protected area.