He graduated from the Lisbon Theatre and Film School, attended the Master Class at the École des Maîtres, and invested in studying abroad, being taught by Robert Castle, Susan Batson, Tom Brangle e Wass M. Stevens.

His wide experience in theatre was built with the acting of pieces by renowned playwrights, like Bertold Brecht, William Shakespeare, August Strindberg, Heiner Muller, Georges Perec, Beaumarchais, Ferenc Molnár and Pierre Corneille.

On 20 November 2023, American writer and filmmaker known as A.M. Lukas, real name Anna Martemucci (who directed the romantic comedy Hollidaysburg),[2] sued Nuno Lopes in a New York court for alleged rape.

[3] According to testimony released that week, Nuno Lopes had allegedly drugged her on 28 April 2006, at an event that was part of the Tribecca Film Festival in New York, and raped her at his rented apartment before calling a taxicab for her.

[4] Lopes denied any wrongdoing and said: "My decision to refuse a confidential settlement and publicly go to court has consequences for my personal and professional reputation."