Throughout his early years, Roque won several awards at festivals and singing competitions and gained national recognition for his energetic television performances and androgynous image.

His performance as John Darling was praised for its employment of comedy, dance, singing, mime and acrobatics by Le Figaro, France Inter and Financial Times.

In 2018, he made his feature-film debut playing an illiterate 20-year-old in Best Intentions, starring opposite Agnès Jaoui, and participated as a guest columnist in the program Bons Baisers d'Europe on France 2.

[15][16] In 2017, Nuno Roque joined #RightsOutLoud, a global campaign by the United Nations to help promote the Universal Declaration of Human Rights through multilingual videos, alongside figures such as António Guterres and Paulo Coelho.

Roque recorded videos, in English, Portuguese and French, for an educational platform that aims to broaden access to the Declaration to millions of illiterate and visually impaired.