[8] A notable incident during her stint was the leading of an ABVP mob to heckle S. A. R. Geelani in a faculty seminar on 'Communalism, Fascism and Democracy: Rhetoric and Reality'.

In 2015, at age 30, she was given the ticket for contesting against Arvind Kejriwal of the Aam Aadmi Party (AAP) in the 2015 Delhi Legislative Assembly election.

[12][8][17] On 26 May 2022, Sharma participated in a debate on the Gyanvapi Mosque dispute on the News24, Republic Bharat & Times Now television channel, during which she repeatedly made derogatory and hateful remarks regarding the beliefs of Islam & age of Muhammad's wife Aisha at the time of their marriage and consummation of the marriage on all the three channels.

Aishwarya, the anchor on Republic Bharat, cautioned her against making any personal comments and from offending anyone's religious sensibilities.

[22] A day later, the video clip of her comments were cut-out and shared by Mohammed Zubair, an Indian-journalist and co-founder of Alt News, on social media.

[25] Nonetheless, Sharma tried to defend her comments and accused Zubair of heavily editing the original clip, which was denied by Pratik Sinha, the other co-founder of Alt News.

[28][19] A police FIR (First Information Report) was registered against Sharma in Mumbai the next day on the grounds of "hurting religious sentiments".

[26] A bandh (shut down) was called by a Muslim organisation in Kanpur to protest the remarks on 3 June, during which violence erupted with 40 people getting injured.

By 4 June, "insult to Prophet Mohammed" was among the top 10 trending hashtags in all the countries of Gulf Cooperation Council (GCC) and Turkey.

The judges also observed that "her outburst is responsible for the unfortunate incident at Udaipur" - a reference to the beheading by two Muslim men of a Hindu tailor who had supported Ms Sharma on social media platforms.

[46] The Indian Supreme Court refused to consolidate multiple FIRs filed in several states against Nupur Sharma, a decision that Supreme Court lawyers Indira Jaising and Ashish Goel criticised as going against "long-standing judicial precedents and standards of prudence and predictability in the administration of the criminal justice system.

"[47] In October 2024, Sharma claimed at a Brahmin conference in Bulandshahr that Gopal Mishra was shot "35 times" and was tortured.

In her apology, posted on X (formerly Twitter), Sharma wrote, “What I repeated about the late Ram Gopal Mishra was based on what I heard in the media.