Shortly after winning the title however he began to focus on turning professional and retired a successful amateur career undefeated.
his first defeat came on 16 June 2001 to Ukrainian Kostyantyn Okhrey, with Seferi being unable to continue in the 4th round due to a rib injury.
On 7 July 2012 Seferi made his comeback fight following his operation against Giulian Ilie in Bern, Switzerland before the Wladimir Klitschko v Tony Thompson bout.
He has fought well-known boxers like Nenad Stankovic, Gusmyr Perdomo, Douglas Otieno Okola, and Giulian Ilie.
In December 2011, Nuri and his brother Sefer were named honorary citizens of their birthplace, Gostivar in Macedonia by the city's mayor Rufi Osmani.