It is situated along the Straits of Johor at the southern end of the Malay Peninsula, it is also the southernmost city of continental Eurasia.

[3][4] Historically, the area surrounding present-day Iskandar Puteri consisted mostly of fishing villages, populated by Malays and Orang Laut tribes.

According to a story from Yayasan Warisan Johor, during his journey to Sempit Puteri, the paddle of the sampan that Dato Jaafar was boarding broke.

In 1993, during the leadership of the fourth Prime Minister Mahathir Mohamad, a plan for a second bridge connecting the Peninsular Malaysia and Singapore was brought forward by Halim Saad.

Saad was as a young entrepreneur who built Malaysia's longest highway, North-South Expressway, and apprentice to the former Minister of Finance Daim Zainuddin.

His past experience enabled Halim to secure financing from Bank for Renong Berhad (now UEM Group) to acquire vast land along with the Second Link for a new township which was eventually deemed Nusajaya.

UEM also sold part of Nusajaya land to other developers including Syed Mokhtar Albukhary's Tradewind, SP Setia (Bukit Indah & Setia Eco Garden), Ecoworld (Eco Botanic), and Sunway Group (Sunway Iskandar) to expedite the development of Nusajaya.

[9] Due to electoral division by Election Commission of Malaysia, there are four parliamentary and eight state constituencies (DUN) dividing the Iskandar Puteri area.

Columbia Asia Iskandar Puteri was the first hospital to be built in the city, followed by Gleneagles Medini and Kensington Specialist Centre.

[14] Concurrent with the development of Iskandar Puteri, a new proposal was brought forward by the then State Secretary, Dato Ayob Mion, to build a new port at the west coast of Johor.

[17] In March 2019, works on a new marina in Puteri Harbour kicked off, as a joint venture between SUTL Enterprise and UEM Sunrise.

[18][19] The first phase of the ONE°15 Marina Puteri Harbour[20] membership was launched in November 2020, with the opening of ONE°15 Estuari Sports Centre.

[21][22] Johor Tourism, Youth and Sports Committee chairman, Datuk Onn Hafiz Bin Ghazi was the guest of honour at the opening launch.

The Malaysia–Singapore Second Link was built between Kampong Ladang at Tanjung Kupang, Johor and Jalan Ahmad Ibrahim at Tuas, Singapore.