Nusco (Irpino: Nùscu) is a town and comune in the province of Avellino (Campania region) in the south of Italy, east of Naples, with a population of around 4,100.

The Lombards built a castle in Nusco to defend the valley from the Ofanto river to the Calore.

In addition to the high death toll, the plague irrevocably changed Nusco's social structure.

For years, Nusco experienced the poverty and misery typical of rural towns.

In the late 19th century, families left Nusco for other, wealthier regions of Italy, as well as for new opportunities in South America and the United States.