Nykøbing was the seat of the former Dueholm monastery, now part of the Morsland Historical Museum.

Nykøbing was the place of birth of Danish-Norwegian author Aksel Sandemose and the reputed inspiration for the fictional town of Jante, associated with the Jante Law, in Sandemose's novel A Fugitive Crosses His Tracks.

Søren Larsen and Sons owned a shipyard in Nykøbing Mors.

Approximately half of the island's residents live in the area around Nykøbing.

Located just outside the town on a spit is Nykøbing Mors Cricket Club Ground.