[4] Nyssa aquatica trunks have a swollen base that tapers up to a long, clear bole, and its root system is periodically under water.

Nyssa aquatica's genus name (Nyssa) refers to a Greek water nymph;[5] the species epithet aquatica, meaning ‘aquatic’, refers to its swamp and wetland habitat.

One of the species' common names, tupelo, is of Native American origin, coming from the Creek words ito ‘tree’ and opilwa ‘swamp’; it was in use by the mid-18th century[6] A large mature tree can produce commercial timber used for furniture and crates.

Many kinds of wildlife eat the fruit, and it is a favored honey tree.

[4] The current world record Water Tupelo tree is located in White County, Arkansas.