Nyuksenitsa (Russian: Ню́ксеница) is a rural locality (a selo) and the administrative center of Nyuksensky District, Vologda Oblast, Russia, located on the left bank of the Sukhona River.

[8] At the time, the Sukhona was intensively used as a transport waterway, connecting Moscow to Arkhangelsk, till 1703 the main hub of Russian foreign trade.

In 1918, the area was transferred to the newly established Northern Dvina Governorate, and in 1924 the uyezds were abolished in favor of the new divisions, the districts (raions).

Nyuksensky District was established on June 25, 1924 and included areas of former Solvychegodsky and Velikoustyugsky Uyezds.

Another paved road branches off in Nyuksenitsa northwest to Tarnogsky Gorodok and further to Oktyabrsky in Arkhangelsk Oblast.