O'Brien is an unincorporated community in Shasta County, California, United States.

O'Brien is located along Interstate 5 16 miles (26 km) north of Redding.

O'Brien has a post office with ZIP code 96070, which was established in 1945.

[2] The community is named after Con O'Brien, who had a resort in the community.

This Shasta County, California-related article is a stub.