The arena was used for artistic gymnastics and trampolining, and also hosted the finals of the basketball matches at the 2004 Summer Olympics.

[11] Renovation of the building for the Olympics was completed on 30 June 2004, and it was officially reopened on 10 August 2004, shortly before the beginning of the games.

The Indoor Hall is the regular home court for the Greek Basket League professional basketball club Panathinaikos.

The arena was used to host the quarterfinals, semifinals, and finals stages of the 1998 FIBA World Championship.

Some of the entertainers who have performed at the arena include Bryan Adams, Maluma, Rotting Christ, Pearl Jam, Enrique Iglesias, Depeche Mode, Jennifer Lopez, Björk, Beyoncé, Slayer, Roger Waters, Aloha from Hell, Tokio Hotel, Helena Paparizou, Sakis Rouvas, Anna Vissi and Cigarettes After Sex.