Founding members of the league were the Arthur Aces, Brooklin Merchants and St. Clair Storm.
Burlington Chiefs, Owen Sound Woodsmen and Six Nations Crash and were accepted for the 2001 season.
Barrie won the league championship in their inaugural season and immediately moved to Major Series Lacrosse in 2005.
In 2009, the Owen Sound Woodsmen became the first team in league history to win back-to-back Presidents Cups championships.
At the beginning of the 2010 season the Nitro changed their name to Norwood Champs, then Ennismore James Gang in 2013.