ONE 162: Zhang vs. Di Bella was a combat sport event produced by ONE Championship that took place on October 21, 2022 at the Axiata Arena in Kuala Lumpur, Malaysia.

[3] A ONE Strawweight Kickboxing World Championship bout for the vacant title between Zhang Peimian and Jonathan Di Bella headlined the event.

[1] Former champion Sam-A Gaiyanghadao announced retired from international competition after returning to Thailand from Singapore and where he had coached at Evolve MMA.

[4] Former Glory Welterweight Champion Nieky Holzken and former ONE Lightweight World Championship challenger Islam Murtazaev were previously scheduled to meet in a lightweight kickboxing bout at ONE: X, but Murtazaev pulled out from the card due to the 2022 Russian invasion of Ukraine, all Russian athletes were removed from the card as a result of the Singaporean government banning them from entering the country and the bout was postponed to this date.

[9] At the weigh-ins, Tagir Khalilov, Constantin Rusu and Gustavo Balart all failed hydration test and were forced to take catchweights.