ONE Friday Fights 22: Prajanchai vs. Sam-A 2 (also known as ONE Lumpinee 22) was a combat sports event produced by ONE Championship that took place on June 23, 2023, at Lumpinee Boxing Stadium in Bangkok, Thailand.

A rematch for the ONE Interim Strawweight Muay Thai Championship between former champions Prajanchai P.K.Saenchai and Sam-A Gaiyanghadao served as the event headliner.

[1] The pair previously faced each other in August 2021 at ONE: Battleground, where Prajanchai won the title by majority decision.

[2] A ONE Heavyweight Championship unification fight between current champion Arjan Bhullar and interim champion Anatoly Malykhin is scheduled to headline the event.

[3] The pair were previously scheduled to square off at ONE 161 and then ONE Fight Night 8, but were moved to this event due to a change in broadcast commitments.