He was elected in a by-election, following the resignation of former premier Brian Pallister, narrowly beating Willard Reaves, the Liberal candidate and another former Winnipeg Blue Bomber.

For high-school, Khan attended Sir Wilfrid Laurier Secondary School and played football and rugby.

In the 2006 CFL season, the Winnipeg Blue Bombers acquired Khan as their first selection in the Ottawa Dispersal Draft.

He was the only member of the Blue Bombers’ offensive line to start all 18 regular season games as well as the football club's East Semifinal contest with the Toronto Argonauts.

Khan's solid play helped running back Charles Roberts rush for a league-leading 1,609 yards on 303 carries.

Khan was named the co-winner of the CJOB Offensive Player of the Game Award in Week 8 versus the Hamilton Tiger-Cats.

GoodLocal, which co-owner Esmail wanted to name LoveLocalMarket, started out in the basement of Shawarma Khan (Graham Ave) and had 100 vendors.

[7] In January 2022, Khan sought the nomination of the Progressive Conservative Party of Manitoba's candidate in 2022 by-election in Fort Whyte.

[8] On 12 February 2022, Khan won the nomination vote for the Fort Whyte by-election that was scheduled to take place on March 22 of that year.

[12] Liberal leader Dougald Lamont questioned whether the process for awarding this grant was fair; he also cited other business that did not receive financial aid from the government.

Khan stated that the result was "a huge honour" noting that he was "one of the first East Indians to play in the CFL, now the first Canadian Muslim to be elected [to the Manitoba Legislative Assembly].