Oberpfaffenhofen is a village that is part of the municipality of Weßling in the district of Starnberg, Bavaria, Germany.

The village is home to the Oberpfaffenhofen Airport (IATA: OBF, ICAO: EDMO) and a major site of the German Aerospace Center (Deutsches Zentrum für Luft- und Raumfahrt, DLR).

The research center in Oberpfaffenhofen houses the DLR, including the Columbus Control Center which DLR operates for the European Space Agency and Airbus Defence and Space, and also some Fraunhofer Institutes and other scientific institutes.

From 2014, OHB group moved the division which formerly was Kayser-Threde, from Munich to Oberpfaffenhofen.

During the occupation of Germany the airport was designated Oberpfaffenhofen Air Force Depot which also served as the maintenance depot for the aircraft that were utilized during the Berlin Airlift of 1948–49.