[3] The first surviving document in which Schleißheim is mentioned comes from the year 785 AD in which Rihpalt von Slivesheim donated his estate to the diocese of Freising.

In the late 19th and early 20th century Mittenheim was the home of German artist Otto Hupp.

[4] During World War II, Oberschleißheim was the location of two subcamps of the Dachau concentration camp.

[5] In the late 1590s, the Duke of Bavaria, William V. built a Renaissance country house (known today as the 'Old Palace') in Schleissheim.

A church report from 1869 tells that Oberschleißheim had 60 houses, most of which were built on the palace canal leading to Dachau.

In the early 20th century, Schleißheim was home to author Waldemar Bonsels, who wrote his children's book "Biene Maja" in 1912.

In 1972 an artificial canoe sprint and rowing venue was created in Oberschleißheim for the Munich Olympic Summer Games.

The airfield and its historic buildings were constructed in 1912 for the Königlich-Bayerische Fliegertruppen (Royal Bavarian Flying Corps).

In the early 1990s the historic maintenance hangar was restored and enlarged to accommodate the Deutsches Museum's growing aviation collections.

The Bavarian Authority of Health and Food Safety,[9] the Institute for Moor Management, the Federal Office for Radiation Protection[10] and the Faculty of Veterinary Medicine for the University of Munich are housed here.

[11] The Helmholtz Research Center is located at the southern-most end of Oberschleissheim, at the city limits of Munich.