[5] As of 2021[update] it is the largest non-profit, academic healthcare system operating in Louisiana, with 40 medical facilities across the state.

[8][9][10] It also has other clinics and medical centers in Greater New Orleans, Baton Rouge, Shreveport, Monroe, Lafayette, and other locations across Louisiana and Mississippi.

[13] During the COVID-19 pandemic in Louisiana, the Ochsner Health System was strained by surges in patient volume.

[14][15][16][17] In 2021 Oschner stated that employees with spouses who did not take the COVID-19 vaccine will pay more for health insurance.

[6] Ochsner reported a drop of $74M in operating income in 2021, attributed to the effects of Hurricane Ida and the COVID-19 pandemic.