Its main economic activities are agricultural, including coffee, corn, cabbage, sugar cane, and onions.

It also attracts residents of smaller neighbouring towns, who come to Ocotepeque to purchase things or to study.

About three hours by bus to the north is the larger city of Santa Rosa de Copán.

The closest airport in Honduras is located approximately 5–6 hours to the north in San Pedro Sula.

The Trifinio Fraternidad Transboundary Biosphere Reserve is a nature preserve shared by Honduras, Guatemala, and El Salvador.