The Astonishing Life of Octavian Nothing, Traitor to the Nation, Volume I: The Pox Party is an American historical novel for young adults written by M. T. Anderson and published by Candlewick Press in 2006.

A sequel was published two years later, The Astonishing Life of Octavian Nothing, Traitor to the Nation, Volume II: The Kingdom on the Waves (Candlewick, 2008).

The greater part of the story is told by a boy named Octavian, who grew up with his mother Cassiopeia, an African princess, in a house full of philosophers and scientists in colonial Boston.

These businessmen own slaves, and it is strongly implied that Sharpe is attempting to bias the experiment with Octavian in order to prove that Africans are inferior.

Octavian's military adventures are narrated mostly in epistolary form by Private Evidence Goring in letters to his sister Fruition.