A brick tunnel leading to Octoraro Creek was built by Charles Spotts[2] and used by slaves travelling the Underground Railway through Lancaster County, Pennsylvania.

The branch enters a steep wooded valley and passes under the Mercer's Mill Covered Bridge at Bailey Crossroads Road.

The branch loops through another steep valley north of Homeville, which widens out before the creek passes under PA Route 896 at Andrews Bridge.

The East Branch widens out into the eastern part of Lake Octoraro about 3 miles (5 km) northwest of Oxford, Pennsylvania.

[citation needed] The West Branch Octoraro Creek runs 15.3 miles (24.6 km)[1] entirely in Lancaster County.

The Scout Reservation contains the original Mason-Dixon Line mile-19 stone monument, along with the remains of a former grist mill along the old camp road.

The creek loops under the high tension lines from the Conowingo Hydroelectric Plant on their way toward Philadelphia and passes by the site of a removed dam.

The six-foot rise in water when the hydroelectric plant is operating inundates this parallel stretch and can cause the Octoraro to reverse flow as far as the 222 bridge.