It was listed on the National Register of Historic Places in 1988, for architectural criteria.

Grenada suffered a tornado on May 7, 1846, which destroyed 112 houses and killed 21 persons.

And it suffered a fire in 1855 which burned about half of the town's buildings.

[3]: 8  And soon after the fall of Vicksburg, Grenada was site of a Union cavalry raid on August 18 and 19, 1863, which overwhelmed a token defensive force and destroyed the town's railway depot, railyard buildings, eighty locomotives and 200 freight cars.

[3]: 8 The cemetery may also include burials of victims of a devastating Yellow Fever epidemic in 1878 which killed at least 363 individuals, including the mayor, of a town of about 2,000 total population.