Oddities is a half-hour documentary/reality television program which follows the operation of an East Village, Manhattan shop which trades in antiques and other rarities.

[5] The store's employees search flea markets, personal collections, auctions, and antique shows for unique and unusual artifacts.

Odd items bought and sold by the shop or featured on the show have included a mummified cat, a rhesus monkey skull, art made from nail clippings, and a straitjacket.

[4][6][7] Celebrities appearing on the show have included Jonathan Davis of the band Korn, Whitey Sterling, singer for the New York band Stiffs, Inc., musician Genesis P-Orridge, actress/comedian Amy Sedaris, actor Matthew Gray Gubler, artist Ann Hirsch, actress Chloë Sevigny, musician Natalia Paruz ('Saw Lady'), video game designer and commercial space flight enthusiast Richard Garriott, director Lloyd Kaufman, nerdcore rapper Schaffer The Darklord, musician Voltaire, musician Moby, artist Cynthia von Buhler, actor/comedian Paul Dinello, burlesque dancer Dita Von Teese, and "High Pitch Eric" of The Howard Stern Show.

This series focuses on another antiques store, Loved to Death, which is located in San Francisco's Haight-Ashbury district.