Part of the Guji Zone, Odo Shakiso is bordered on the south by the Dawa River which separates it from Arero, on the west by Bule Hora, on the northeast by Uraga, on the north by Bore, on the northeast by Adolana Wadera, and on the east by Liben.

Gold has also been extracted by placer mining from the Awata River, which flows between Shakiso and Megado.

A hydro-electric power station over the Mormora River was inaugurated by Emperor Haile Selassie in March 1965.

[3] Odo Shakiso was one of four woredas that suffered from a wildfire that was started 10 February 2000 and was not brought under control until 7 April, after it had burned a total of 70,000 hectares.

Losses to wild animals, the displacement of eight households and damages to bee hives were also reported.