He became a Cardinal of the Roman Catholic Church in 1591, and briefly acted as regent of the Duchy of Parma and Piacenza for his nephew Odoardo from 1622 to 1626.
Cardinal Odoardo is probably best known today for commissioning the Bolognese artist Annibale Carracci to fresco the Camerino in the Palazzo Farnese in Rome.
Carracci undertook this from 1595 to 1597, just prior to starting his decoration of the more famous and elaborate Farnese Gallery in the same palace.
It was on Carracci's recommendation that he commissioned Domenichino to fresco the Chapel of St Nilo in the abbey at Grottaferrata.
[2] His patronage of architecture was less extensive but included the Casa Professa, the Jesuit house adjacent to the church of the Gesu in Rome, by the architect Girolamo Rainaldi.