Odon Guitar (August 31, 1825 – March 13, 1908) was a general in the Union Missouri State Militia during the American Civil War.

He was noted for his successful campaign against Joseph C. Porter and John A. Poindexter's recruiting commands in northern Missouri.

He left to participate in the California gold rush, returning to Columbia, Missouri, to resume his law practice in October 1851.

Guitar then turned to pursuing Poindexter, overrunning him and completely scattering his command at the Battle of Compton's Ferry and the subsequent fight at Yellow Creek.

As a slaveholder himself and attempting to respect the rights of Southerners in his district, he received severe criticism from more radical Unionists.

Guitar was president of the Boone County Bar Association until 1878 and he achieved a legendary record of success in defending homicide cases.