Odrisamer Despaigne Orue (/ˈoʊdriːsəmɪər ˈdɛspɑːnjeɪ/ OH-dree-sə-meer DES-pahn-yay;[1] born 4 April 1987) is a Cuban professional baseball pitcher for the Leones de Yucatán of the Mexican League.

He played for the Cuban national baseball team, and defected from Cuba while in Europe for the 2013 World Port Tournament.

[3] Despaigne and fellow Cuban defector Aledmys Díaz held a showcase for Major League Baseball teams on 13 February 2014.

[5] The Padres assigned Despaigne to the San Antonio Missions of the Double-A Texas League, where in two games started, he allowed one earned run in 7+2⁄3 innings pitched.

[8] In his fifth major league start on 20 July, Despaigne pitched 7 2/3 no-hit innings before the New York Mets' Daniel Murphy doubled.

[9] On 4 February 2016, Despaigne was traded to the Baltimore Orioles for minor league pitcher Jean Cosme.

On 1 December 2023, Despaigne's rights were traded to the Leones de Yucatán in exchange for Anthony García.