Of One Blood is a 1944 American race film directed, written by and starring Spencer Williams.

The film focuses on two orphaned African American brothers who grow up to become a lawyer and a police officer, and who work together to break up a crime ring run by a miscreant who turns out to be their long-lost oldest brother.

Like many race films, all of Williams' works were thought to have been lost.

Williams' works recovered in the collection were restored and now held at Southern Methodist University (SMU) as the Tyler, Texas, Black Film Collection.

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