The company operates 960 retail stores in the United States under the Office Depot and OfficeMax brands,[4] as well as e-commerce sites and a business-to-business sales organization.

[8] In 1995, Office Depot entered the Mexican marketplace in a joint venture with Grupo Gigante, making it the retailer's first international expansion.

[9] In December 2001, Viking Direct expanded to Central America with new retail stores in El Salvador, Guatemala, and Costa Rica through a joint licensing agreement.

[13][14] In May 2014, Office Depot announced the closure of four hundred stores, due to declining sales and customer migration to e-retailers.

[15] On February 4, 2015, it was announced that rival Staples had agreed to purchase Office Depot, in a cash and stock deal worth approximately $6.3 billion.

[26][27] In the same year, the company signed on as the primary sponsor of the #99 Ford Fusion, owned by Roush Fenway Racing and previously driven by Carl Edwards.

[30][31] In March 2019, Office Depot and Support.com, Inc., a California-based tech support software provider, agreed to pay a total of $35 million to settle Federal Trade Commission allegations that the companies tricked customers into buying millions of dollars' worth of computer repair and technical services by deceptively claiming their software had found malware symptoms on the customers' computers.