The hospital has a Level III trauma center, an emergency department, and provides numerous inpatient and outpatient services.

[2] The Ohio State University maintains its orthopedic, wound care, and specialty blood vessel surgery programs at the hospital.

The building, a four-story structure on a 7-acre (2.8 ha) plot, opened in 1891, and was dedicated on November 22 of that year by bishop John Ambrose Watterson.

[5] The hospital gained its most distinctive modern feature in 1971 – a tall cylindrical tower with a Modernist design.

In 2018, it was announced that the tower and west wings will be demolished and replaced with more spacious and modern hospital facilities in further years, with a project cost of $26 million.