The corridor that SR 28 currently occupies has been a part of the state highway system from its establishment in 1912.

[2][3] Following a statewide renumbering of state routes around 1923, the current highway became a part of SR 27.

[4] After the establishment of the U.S. highway system in 1926, the designation of US 27 in the southwestern corner of the state resulted in the renumbering of the roadway to SR 28.

Around 1994, a short controlled-access highway opened east of I-275 that bypassed Mulberry.

[8] Prior to 2015, a 0.89-mile-long (1.43 km) concurrency existed along US 50 at SR 28's west end in Milford.