67 concurrency in Kenton, Ohio, and its northern terminus is on Catawba Island in Ottawa County, north of Port Clinton.

From Kenton, State Route 53 moves northeast to Forest, then continues eastward to Upper Sandusky.

It then moves north through the small towns of Tymochtee and McCutchenville before entering Tiffin.

The route then moves due north to Fremont, where it joins a four-route bypass around the city with U.S.

From its eastern bypass interchange, State Route 53 heads north onto Catawba Island.