Its southern terminus was on the East Huntington Bridge over the Ohio River at the West Virginia state line near Proctorville where West Virginia Route 106 continues south.

The majority of SR 607 was on the East Huntington Bridge.

The route started at the Ohio–West Virginia state line over the Ohio River.

Less than one-half mile (0.80 km) later, the route curved to the south and ended at SR 7 and SR 243 near Proctorville.

[1] The East Huntington Bridge was built in 1985,[3] and a year later, SR 607 was designated.