The western terminus of the state highway is at a signalized intersection with SR 257 nearly 2.5 miles (4.0 km) west of Powell, just outside the Columbus Zoo and Aquarium.

The highway travels east to Highbanks Metro Park and Polaris Fashion Place.

After Powell, there is an intersection with SR 315 near the Olentangy River and the northwest corner of Highbanks Metro Park.

SR 750 ends at I-71 at an incomplete partial cloverleaf interchange, and Polaris Parkway continues eastward to Westerville.

The lowest traffic count is near SR 257, where 8,080 vehicles travel the highway on average each day.