OUE sponsored men's and women's basketball, volleyball and golf as a part of the Ohio Regional Campus Conference.

[5] Ohio University Eastern comprises two facilities: Shannon Hall and the Health and Physical Education Center.

The original design of the Belmont County official seal, created by Ohio University alumnus Michael Massa, is located at the Shannon Hall entrance.

The Health and Physical Education Center (completed in 1997) is an athletic facility located between Pittsburgh, Pennsylvania and Columbus, Ohio.

The center is the home to OUE's athletic programs (men's and women's basketball, volleyball, men's and women's cross country, golf) as well as the host to high school playoff contests such as the Ohio Valley Athletic Conference (OVAC) championships and the OHSAA sectional and district finals.