These Native Americans disappeared from the scene just as European colonists were beginning to arrive in North America.

As the east coast was settled, the Native Americans who lived closer to the Atlantic Ocean were exterminated or forced to flee to the west.

Various tribes inhabited the Ohiopyle area at this time, preceding their ultimate removal following the French and Indian War.

"Ohiopyle" is derived from the Lenape phrase ahi opihəle which means 'it turns very white',[4][5] referring to the frothy waterfalls.

George Washington was sent by the colonial governor of Virginia to try to retake the all-important fort at the confluence of the Allegheny and Monongahela Rivers.

His troops encountered and routed a small party of French soldiers in the Battle of Jumonville Glen.

Washington was forced to quickly build a fort to prepare for the oncoming French attack.

The colonial forces of Washington were overwhelmed by the French and their Indian allies in the Battle of the Great Meadows at Fort Necessity.

In 1763 King George III declared the area an Indian reserve and required all European settlers to leave.

This tax had been proposed by United States Secretary of the Treasury Alexander Hamilton, passed by Congress, and signed into law by President Washington in 1791.

The rebels "could never be found," according to Thomas Jefferson, but the militia rounded up twenty prisoners, clearly demonstrating Federal authority in the national government.

This road that passed near Ohiopyle increased the accessibility of the area and connected it to eastern markets.

Tourists flocked to the area to see the waterfalls and stay at the resorts that quickly sprouted up along the Youghiogheny River.

The resorts had boardwalks, dancing pavilions, bowling alleys, fountains, tennis courts, and hiking trails.

Wilderness Voyageurs, under the ownership of Lance Martin, began commercial whitewater rafting on the Youghiogheny River.

Ohiopyle is also near Frank Lloyd Wright's masterpiece, Fallingwater, built in 1936, and this nearby attraction brings tourists through the town.