[1] Due to the lethal side effects of the Ojos Azules gene, breeders stopped working with this blue eye mutation.

Only cats descending from the original foundation female Cornflower and expressing the deep blue eye gene have been called Ojos Azules.

Eventually, breeders stopped working with cats bearing this blue eye mutation and the breed became officially extinct.

[3] Unlike the blue eyes seen linked to the genes in solid white, bicolor, and colorpoint, all of which suppress pigmentation, this gene is not linked to any specific fur color or pattern,[1][3] giving the opportunity to have cats with dark coats and blue eyes.

The blue eye color seen in cats such as the Siamese and the Ojos Azules is due to the same physical phenomenon, the absence of melanin in the iris.

It was discovered that when the gene is homozygous it caused cranial deformities, white fur, a small curled tail, and stillbirth.

However, only particolors (bicolors and tricolors), colorpoints, and intermediate colors with a white tail tip were permitted.

[citation needed] Apart from the extinct Ojos Azules, several other dominant blue eye (DBE) genes have been found in cats worldwide.