Okeene is a town in Blaine County, Oklahoma, United States.

[5] Okeene is located in northeastern Blaine County at the intersection of state highways 8 and 51.

According to the United States Census Bureau, Okeene has a total area of 2.30 square miles (5.96 km2), all land.

St. Anthony of Padua Church was begun on December 20, 1921, and completed in 1924 at a cost of $85,000, not including donated work and materials.

[8] Three NHRP-listed sites are located in Okeene, being the Okeene Flour Mill off Oklahoma State Highway 51, the Sooner Co-op Association Elevator (West) at 302 West F Street, and the Shinn Family Barn to the southeast.