Designated the Division of Narcotics Enforcement, the agency operated under the Attorney General of Oklahoma for the next decade.

Therefore, in 1975, the Oklahoma Bureau of Narcotics was reconstituted, this time more adequately staffed and equipped, and given the necessary autonomy to operate in the war on drugs.

The Bureau has original jurisdiction statewide on all violations of the Uniform Control Dangerous Substances Act as well as crimes of human trafficking.

OBN also provides a leadership role for law enforcement throughout the state for the investigative effort directed towards eliminating the illegal use of controlled dangerous substances.

The Bureau serves as the law enforcement arm of the State government's approach to combating drugs.

The Oklahoma Department of Mental Health and Substance Abuse Services serves as the prevention, education and treatment component.