OSU medical center operates a large number of osteopathic residency and fellowship programs.

The hospital is the largest osteopathic teaching center in the United States, training 135 resident physicians[1] in primary and sub-specialty care each year.

[4] Oklahoma legislators have appropriated $40 million in funding towards improving the hospital's technology and facilities.

[7] The company later became the target of a federal fraud investigation, which eventually pleaded guilty and paid $1.7 billion in fines.

[13] In January 2021, plans were announced to build a 58-bed medical-surgical veteran's administration (VA) hospital on OSU Medical Center's campus.