The area is roughly bounded by Court Avenue at the North, Graham Street on the east, the Ohio River at the south, and Interstate 65 at the west.

Jeffersonville's largest fire wiped out a block in the historic district on January 11, 2004, which destroyed the original Horner's Novelty store.

Across Spring Street from Warder Park is the Old Masonic Temple, built in the early 20th century, with a majestic marble staircase.

Horner's Novelty, a long-time commercial supplier of party supplies and costumes that was rebuilt after a fire, is also included in the landmark boundaries.

From its heyday of the 1850s until the Great Depression in the 1930s, Jeffersonville was the leading center of U.S. steamboat production, due largely to its excellent harbor, which remained the deepest in the surrounding area.

Many individuals who lived in the district worked at the Howard Shipyards, that became Jeffboat in the nearby town of Port Fulton, which was eventually annexed into Jeffersonville.

The majority of the commercial buildings along Spring Street are Italianate styles and Gothic Revival churches reflecting the large immigrations from Ireland and Germany that came during the time period.

However, with the construction of Youngstown Shopping Center 1.5 miles (2.4 km) northwest of the downtown area on 10th Street/Indiana State Road 62, the district began its decline.

It contains the Old Strauss Hotel at the corner of Riverside Drive, a three-story Italianate hostelry with a corbeled cornice and arched windows.

[14] North of Market Street, few buildings remain that date before 1850, making the character of the district during the early time frame unknowable.

St. Augustine Roman Catholic Church, a Spanish-flavored neo-Baroque structure with a Moorish-styled rectory, is located on the 300 block of East Chestnut.

The Olde Towne Grocery, originally built in the 1920s as a Krogers and later an A&P, and a collectibles store named Hockeyman's are located across from each other on the 100 block of East Maple.

This allows for Warder Park and eastern residential areas, but not the current Jeffersonville Township Public Library and the Clark County Courthouse.

This was the site of the Falls City Area Center, a community college that eventually moved to New Albany and became Indiana University Southeast.