[3] It originally met in a log structure located in the present-day Old Kingsport Presbyterian Church cemetery.

[3] Under Ross' leadership, the church grew rapidly, quickly outgrowing its log building.

The building is considered a fine example of Greek Revival architecture and is one of the oldest extant structures in Kingsport.

The American Civil War led to a period of decline in both Kingsport and the church.

Membership slowly declined in the decades following the war, with a long series of pastors each serving for brief periods during this time (1865–1910).

He oversaw the building's renovation, as well as the construction of three levels of Sunday School rooms attached to the back of the old sanctuary, as well as a basement.

The church building was moved to its current location off of Stone Drive (U.S. Route 11W) in the summer of 1953 to land donated by Mrs. Octavia Patton.

In recent years, the historic building has received a number of repairs and updates, plus quite a bit of beautification, inside and out.