Old Main is located on the southwest corner of the intersection of Cass and Warren Ave. in the busy Midtown area of Detroit.

The structure was designed by architects Malcomson & Higginbotham and contained 103 classrooms, laboratories, offices, and space for 2,000 students.

In 1923 this would become the four-year degree granting College of the City of Detroit, one of the main precursor institutions of today's Wayne State University.

By the 1980s though, falling ceilings, peeling paint, vandalism, a fire, plumbing failures, leaking roofs, and deferred maintenance had taken their toll on Old Main.

Today, the renovated Old Main serves as the home of the College of Liberal Arts and Sciences of Wayne State University as well as accommodating many other classes in a wide variety of subjects.