Its front facade, facing Telfair Street, has a projecting Greek temple portico, with six massive fluted Doric columns supporting an entablature and gabled pediment.

The interior housed what were, for the 1830s, generous quarters for a medical school, including several laboratory spaces, lecture halls, and a library.

This building was built as its main facility in 1835 to a design by Charles Blaney Cluskey, one of America's early trained architects and a proponent of the "new" Greek Revival style.

It saw use over much of the remaining 20th century by a variety of organizations, notably including the Sand Hills Garden Club, under whose tenure the latticework brick fence was built (1933), and the grounds landscaped.

In 1987, the building was acquired by the Medical College of Georgia Foundation, which restored it to its 19th-century appearance, while also upgrading its systems to modern standards.